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    山東省出生缺陷研究與轉化協同創新中心

    出生缺陷是指任何出生時已存在的影響人體結構和功能的異常。中國是世界上出生缺陷高發國家之一,每年約有90萬出生缺陷的嬰兒出生,占出生人口的5.6%。山東省是出生缺陷的高發地區,2007-2010年山東省人群結構異常出生缺陷發生率分別為107.44/萬、82.86/萬、141.29/萬和124.64/萬,從高到低依次為先天性心臟病、多指(趾)、總唇裂、腦積水、神經管缺陷、肢體短縮等。如果將先天性功能異常列入,如先天智障、先天性耳聾、先天性精神疾患(如孤獨癥)等,則出生缺陷的數據會大大增加。因此,出生缺陷已經成為我國重大的社會問題,也是山東省急需解決的健康問題。

    我國在出生缺陷創新與轉化方面面臨著一些共性和特殊的機制體制問題,主要表現在:科研評價機制不合理導致共享合作成功案例不多,常常是遺傳學和基因組學基礎研究人員找不到合適的、對科研感興趣的臨床專家合作,或是基礎研究的重要發現無法實現臨床轉化應用;缺少多學科深度交叉和融合的學術文化致使單獨遺傳學或基因組學一個學科的簡單研究居多;缺少臨床遺傳學獨立學科和專業化隊伍,許多遺傳病都不能正確診斷,致使許多寶貴遺傳病家系或病例資源流失;缺少分工、協作的全國性網絡,研究力量分散,致使多中心、大樣本的遺傳檢測的數據少之又少;缺少具有扎實生物信息學、基因組學和遺傳學理論和技術知識的人才,致使許多由國家重金投入購置的高、精、尖技術平臺使用效率非常低,科研產出更少。因此急需在體制上有所突破,才有可能打破目前的僵局。

    目前出生缺陷亟待解決的問題主要有五個:(1)明確致病基因,闡明發病機制。(2)疾病的早期預警和早期診斷。(3)治療方法的探索與研制。(4)出生缺陷新藥研發及臨床轉化。(5)出生缺陷基因的“保護”和“利用”。圍繞這五個關鍵問題,按照“山東急需、區域優勢、國家領先”的要求,濟寧醫學院計劃與國內著名高校及企業合作,瞄準《國家中長期科技發展規劃綱要(2006-2020)》的重大需求和“人口與健康”國家戰略目標,按照“需求導向、全面開放、深度融合、創新引領”的原則,組建由著名大學和高新技術企業強強聯合和優勢互補的協同創新中心。中心將凝聚一流的學術隊伍,探索形成協同創新模式和機制,顯著提升創新能力。通過中心協同管理機制、跨校人員聘任、跨校人員評價、協同研究、資源共享及合理配置、成果共享、合作交流、創新文化建設等方面的改革,推進高校科技機制改革,建立協同創新模式和機制,實現組織管理、人員團隊、人才培養、科研組織、資源共享五個方面的協同,提升持續創新活力,實現重大出生缺陷研究、醫學轉化以及產業化的重大突破。中心將充分發揮協同創新優勢,圍繞重大科學任務,開展聯合攻關,解決重大問題,形成重大成果。主要成果形式:(1)形成協同創新機制和模式;(2)建設引領學術前沿的協同創新公共平臺;(3)形成和完善高水平人才培養模式;(4)發表高水平研究論文;(5)產生有重要應用開發潛力的發明專利、早期診斷產品和新型治療藥物;(6)建成出生缺陷重大疾病基因組學數據庫。

    參加協同創新中心的主要單位包括:(1)濟寧醫學院:擁有山東省神經生物學重點實驗室、行為醫學重點實驗室、心臟疾病診療重點實驗室,中英聯合分子醫學與神經生物學實驗室,中美聯合轉化醫學實驗室,神經病學、病理學與病理生理學重點學科,行為與健康人文社科研究基地。是中華醫學會行為醫學分會和山東省行為醫學分會主任委員的掛靠單位,主辦國家級《中華行為醫學與腦科學雜志》(基礎醫學排名第一)。擁有山東省內唯一的精神醫學本科專業和國內領先、特色鮮明的精神醫學-行為醫學-應用心理學-神經生物學學科群,擁有山東省建院最早、國內開放病床數最多的精神病專科醫院(山東省安康醫院)。在精神神經疾病、心臟病、遺傳性腫瘤等重要疾病的發生、發展及治療方向研究具有國內領先、國際一流的水平。(2)復旦大學分子醫學教育部重點實驗室:該實驗室成立于2002年,重點研究方向集中在代謝性疾病、惡性腫瘤、出生缺陷和生物技術新藥研制。在20世紀90年代就成功地完成了重組鏈激酶的研制、開發和臨床應用,取得了新藥證書和生產批件,曾獲上海市科技進步一等獎、國家科技進步二等獎和國家發明金獎。(3)上海交通大學Bio-X研究院:現任院長為賀林院士,研究方向包括精神疾病的病因及分子機制、疾病基因組學、藥物基因組學、營養與健康、發育與生殖等。發表SCI論文300余篇,主編和參編專著15部,申請和獲取專利20多項。(4)上海佰臻基因組學與人類健康研究院:該研究院由賀林院士擔任首席科學顧問,馬端教授任院長,聯合了一批中外卓有成就的遺傳學家、醫學家、生物學家、營養專家、生物信息學專家,共同組成一個充滿活力的科研及轉化醫學機構,主要致力于轉化醫學研究及服務。已建立完善的基因組學、轉錄組學、蛋白質組學、代謝組學和生物信息學研究平臺,在出生缺陷三級預防、個體化用藥(基因檢測指導臨床用藥)、個體營養狀況評估及干預、疾病病因和發病機制研究進行了卓有成效的研究及轉化。(5)山東魯抗辰欣藥業有限公司:國家重點高新技術企業,擁有國家博士后科研工作站、山東省抗生素藥物工程技術研究中心和山東省企業技術中心。研制成功國家級新藥60 多個,申請國家專利36 余項,獲得授權專利19 項。

    通過本中心的建設,將集聚和培養一批在遺傳性精神神經疾患、先天智障、先天性心臟病、遺傳性腫瘤、藥物基因組學等方面的拔尖創新性人才,取得一批在生物醫學領域有重大影響的標志性成果,爭取在10年左右時間內將中心建設發展成為國內領先、國際一流的出生缺陷創新高地、新技術研發和產業引領陣地,成為遺傳醫學和基因組醫學臨床服務及培訓基地,為提高人口健康水平、建設創新型國家做出貢獻。

    計算機科學與技術專業(軟件外包方向)

    什么是軟件外包?

    軟件外包是國家近年來大力推廣和支持的新型技術外包,是企業為了專注核心競爭力業務和降低軟件項目成本,將軟件項目中的全部或部分工作發包給提供外包服務的企業完成的軟件需求活動。軟件外包專業正是為了適應軟件外包事業發展而開設的一門計算機軟件工程類的新興專業。目前國家非常重視并給予大量優惠政策支持軟件外包行業的發展。

    軟件外包專業方向的最大特色

    我校計算機科學與技術專業(軟件外包方向)是校企合作,在校學習的是校企根據市場需要聯合創作的教材,針對性很強,第四年用1年的時間,到公司頂崗實訓,完成從學生到軟件工程師的轉變。最大特色是訂單式培養,即被錄取為該專業方向的同學,經過四年學習,成績合格、達到濟寧醫學院本科畢業和學位授予條件的,獲得濟寧醫學院普通本科畢業證書,授予工學學士。并百分之百就業。

    軟件外包專業方向培養目標

    培養適應社會經濟發展需要、具備良好的科學素養、系統地掌握計算機科學與技術的專業基礎知識,具有較強的軟件工程實踐能力和外語溝通能力,能夠從事軟件開發、軟件測試、系統維護、項目管理等工作的高級技能型人才。學生畢業后能在軟件外包企業從事對日軟件設計、開發、測試、銷售、維護等工作,也能夠在企業、事業和行政管理等單位從事計算機科學技術相關的教學、科研和應用工作。

    軟件外包專業方向社會需求情況,學生畢業后就業方向與待遇

    作為伴隨計算機科學與技術發展起來的新興產業,當前世界軟件外包市場發展迅速,我國軟件外包服務產業專業人才短缺,急需高端專業人才,目前已得到了政府的積極倡導和特殊扶持,就業前景廣闊。

    本專業學生是專門針對IT企業需求培養的,通過系統的學習和實訓,畢業后能夠在各類專業的軟件外包公司和相關的軟件外包IT企業擔任軟件設計師、軟件工程師;能夠承擔國內外,特別是對日外包的多種信息管理系統的開發工作,能夠迅速完成從學生到企業人才的轉變,完全適應企業的工作環境和管理體制,最短時間內成長為一個優秀的應用技術型軟件外包人才。畢業后還可以在高校或科研機構從事科研和教學工作,畢業生還可以有報考研究生、公務員、選調生等一系列選擇。

    達到企業軟件外包工程師資格的畢業生,目前在一線城市最低月薪在5000元左右,二三線城市最低月薪在3000元左右。根據國內最權威第三方教育數據咨詢和評估機構——麥可思研究院2012年6月11日公布的2012年中國大學生就業報告》(就業藍皮書),軟件工程專業學生畢業三年后平均月薪達7515元,列全國高校所有專業之首。

    “121質量工程”與軟件外包人才培養

    本專業采用校企合作“121質量工程本科應用型人才培養”模式,主要承擔對日外包。“1”是指大學一年級一年的時間,高校負責通識課教育,重點強化日語教育。“2”是大學二年級、三年級兩年的時間,高校、企業共同負責基礎課和專業課,校企合作共同開發適應課堂和市場需要的課改課程。“1”是大學四年級一年的時間,學生到企業頂崗實習,結合市場需要進行實訓,親自參與對日外包項目,在學習的同時,還可以獲得企業發給的一定的生活補貼,還可以獲得多項資格認證,成為企業所需的人才。

    學費收取標準

    軟件外包專業方向是校企合作辦學,需要對現有教學體系進行較大幅度改造和嫁接,課改比例達60%,專業課程主要是社會與市場急需的技術與專業知識。校內師資配備、設施配備及企業優質資源利用等比一般本科專業均有更高的要求,另外,訂單式培養也需要更多資金支持。因此,學費標準略高于一般本科專業,但遠低于中外合作辦學專業;根據山東省人民政府規定的標準,學費為每生每年8000元。

    計算機科學與技術專業(物聯網方向)

    什么是物聯網?

    自2009年8月溫家寶總理提出“感知中國”以來,物聯網被正式列為國家五大新興戰略性產業之一,寫入“政府工作報告”,我省也出臺了《山東省物聯網產業發展規劃綱要(2011—2015)》。物聯網(Internet of Things)是通過射頻識別(RFID)、紅外感應器、全球定位系統、激光掃描器等信息傳感設備,按約定的協議,把任何物品與互聯網相連接,進行信息交換和通信,以實現智能化識別、定位、跟蹤、監控和管理的一種網絡概念。“物聯網概念”是在“互聯網概念”的基礎上,將其用戶端延伸和擴展到任何物品與物品之間,進行信息交換和通信的一種網絡概念。像我們常見的公交卡、高速公路上的ETC等識別系統均屬于該領域范疇。

    我校物聯網專業方向的特色

    我校計算機科學與技術專業(物聯網方向)是校企合作,在校學習的是校企根據市場需求聯合創作的教材,針對性很強,第四年用1年的時間,到公司頂崗實訓,完成從學生到物聯網工程師的轉變。最大特色是訂單式培養,即被錄取為該專業方向的同學,經過四年學習,成績合格、達到濟寧醫學院本科畢業和學位授予條件的,獲得濟寧醫學院普通本科畢業證書,授予工學學士。并百分之百就業。

    “121質量工程”與物聯網專業人才培養

    采用校企合作“121質量工程”本科應用型人才培養模式,即:“1”是指大學一年級一年的時間,由高校負責進行通識課教育。“2”是大學二年級、三年級兩年的時間,由高校、企業共同進行基礎課和專業課教育,以市場為導向,校企合作共同開發適應市場需求的課程體系。“1”是在大學四年級用一年的時間,到物聯網高新產業相關企業接受一線工程師培養,在企業環境下通過頂崗實訓和畢業實習加強實踐能力的培養,實踐周期是一般普通本科專業的三倍,通過強化專業實踐打造基礎雄厚,實踐能力強,快速融合所在企業要求的物聯網人才。實習期間,將獲得企業提供的生活補貼。

    物聯網專業方的社會需求情況與就業崗位

    實習期間由合作單位負責推薦學生實現高質量就業,合作方鄭重承諾每屆能拿到畢業證、學位證的學生就業率100%。根據國內最權威第三方教育數據咨詢和評估機構——麥可思研究院2012年6月11日公布的2012年中國大學生就業報告》(就業藍皮書)調查結果顯示:畢業三年后平均月收入排名前十位,計算機、網絡工程相關專業的占一半,并且月收入都在6000元以上。

    當前世界物聯網市場發展迅速,物聯網正式列入國家重點發展的五大戰略性新興產業之一,我國物聯網產業急需高端專業人才,國家將在多方面給予政策支持,目前該辦學項目得到了政府的積極倡導和重點扶持。

    本專業培養的學生是專門針對社會和市場需求培養的,通過系統的學習和實訓,主要就業于與物聯網相關的企業、行業,將從事物聯網的通信架構、網絡協議和標準、無線傳感器、信息安全等的設計、開發、管理與維護,也可在高校或科研機構從事科研和教學工作, 專業應用范圍廣,就業前景樂觀。畢業生還有報考研究生、公務員、選調生等一系列選擇。

    物聯網專業方向學費標準

    由于本專業需要對現有教學體系進行較大幅度改造和嫁接,課改比例達60%,專業課程主要是市場亟需的專業知識;校內師資配備、設施配備及企業優質資源利用等較一般本科專業均有更高的要求;另外,訂單式培養也需要更多資金投入。因此,學費標準略高于一般普通本科專業,但遠低于中外合作辦學專業的收費;根據山東省人民政府規定的標準,學費標準為每生每學年8000元。

    物聯網專業方向的培養目標

    培養適應國家現代化建設需要,具有基礎厚、口徑寬、能力強、綜合性、素質高等特點的,具有良好的科學素養、扎實的電子技術、現代傳感器和無線網絡技術、信息處理、網絡通信理論、計算機技術等基本理論和技能,掌握物聯網系統體系結構,能從事物聯網領域的基礎理論、系統設計、系統分析與科技開發及研究方面的高層次應用型人才。畢業后能在各級醫院、信息產業、科研機構、教育單位等從事計算機科學與技術相關的硬件、軟件設計與開發、物聯網系統綜合研究開發集成及應用等工作。

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